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BGB-A445, a novel non-ligand-blocking agonistic anti-OX40 antibody, exhibits superior immune activation

Frontiers of Medicine doi: 10.1007/s11684-023-0996-8

Abstract: OX40 is a costimulatory receptor that is expressed primarily on activated CD4⁺, CD8^{+OX40 to its sole ligand OX40L potentiates T cell expansion, differentiation, and activationTherefore, the use of agonistic anti-OX40 antibodies for cancer immunotherapy has gained great interestHowever, most of the agonistic anti-OX40 antibodies in the clinic are OX40L-competitive and show limitedTaken together, our findings show that BGB-A445, which does not block OX40–OX40L interaction in contrast}

Keywords： BGB-A445 OX40 agonistic antibody OX40L noncompetitive

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Effect of IL-10 on formation of foam cell induced by ox-LDL

WANG Fei, DAI Yalei, XU Ting, XU Bo, WANG Kaifeng

Frontiers of Medicine 2008, Volume 2, Issue 3, Pages 298-302 doi: 10.1007/s11684-008-0057-3

Abstract: The cells were further stimulated by ox-LDL, ox-LDL plus LPS, ox-LDL plus IL-10 and LPS.The maximum increase of about 40% was observed.These results indicated that IL-10 can effectively prevent the formation of foam cells induced by ox-LDLThis study demonstrates that ox-LDL can cause foam cell formation from macrophages .IL-10, an anti-inflammatory cytokine, can inhibit the effect of ox-LDL and LPS.

Keywords： inflammatory presence interleukin-10 dose-dependent ox-LDL

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The Potential Role of Powdery Mildew-Resistance Gene Pm40 in Chinese Wheat-Breeding Programs in Perspective

Shengwen Tang,Yuting Hu,Shengfu Zhong,Peigao Luo

Engineering 2018, Volume 4, Issue 4, Pages 500-506 doi: 10.1016/j.eng.2018.06.004

Abstract: Pm40 was identified and mapped on the wheat chromosome arm 7BS from several wheat lines developedPm40 offers a broad spectrum of resistance to Bgt, which suggests that it is likelyLines with Pm40 and promising agronomical traits have been released by several wheat-breedingTherefore, we believe that Pm40 will play a role in powdery mildew-resistance wheat breedingIn addition, both Pm21 and Pm40 were derived from alien species, suggesting that the

Keywords： Wheat Powdery mildew Pm21 Pm40 Alien species Native resistance

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Coming Back from a Trip on High-Speed Trains in the 2040s

Ignacio Barron

Engineering 2016, Volume 2, Issue 3, Pages 292-293 doi: 10.1016/J.ENG.2016.03.020

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Efficacy through the Gut Microbiota: A New Field of Traditional Chinese Medicine” [Engineering 5 (2019) 40 Corrigendum

Yan-Meng Lu, Jiao-Jiao Xie, Cong-Gao Peng, Bao-Hong Wang, Kai-Cen Wang, Lan-Juan Li

Engineering 2019, Volume 5, Issue 4, Pages 811-812 doi: 10.1016/j.eng.2019.05.004

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Comments on the special issue on forestry of

John L. INNES

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 4, Pages 502-503 doi: 10.15302/J-FASE-2017189

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PD-1/PD-L1 blockade in cervical cancer: current studies and perspectives

Yumeng Wang, Guiling Li

Frontiers of Medicine 2019, Volume 13, Issue 4, Pages 438-450 doi: 10.1007/s11684-018-0674-4

Abstract: Checkpoint blockades targeting the PD-1/PD-L1 axis have achieved effective clinical responses with acceptableIn this review, we summarize recent advances in our understanding of the PD-1/PD-L1 signaling pathway, including the expression patterns of PD-1/PD-L1 and potential PD-1/PD-L1-related therapeutic strategies

Keywords： PD-1 PD-L1 immune checkpoint blockade antibody immunotherapy cervical cancer

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In memory of Perry L. McCarty, seminal founder of Environmental Biotechnology

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 10, doi: 10.1007/s11783-023-1730-0

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Shear design of high strength concrete prestressed girders

Emad L. LABIB,Hemant B. DHONDE,Thomas T. C. HSU,Y. L. MO

Frontiers of Structural and Civil Engineering 2014, Volume 8, Issue 4, Pages 373-387 doi: 10.1007/s11709-014-0087-7

Abstract: Normal strength prestressed concrete I-girders are commonly used as the primary superstructure components in highway bridges. However, shear design guidelines for high strength PC girders are not available in the current structural codes. Recently, ten 7.62 m (25 feet) long girders made with high strength concrete were designed, cast, and tested at the University of Houston (UH) to study the ultimate shear strength and the shear concrete contribution ( ) as a function of concrete strength ( ). A simple semi-empirical set of equations was developed based on the test results to predict the ultimate shear strength of prestressed concrete I-girders. The UH-developed set of equations is a function of concrete strength ( ), web area ( ), shear span to effective depth ratio ( / ), and percentage of transverse steel ( ). The proposed UH-Method was found to accurately predict the ultimate shear strength of PC girders with concrete strength up to 117 MPa (17000 psi) ensuring satisfactory ductility. The UH-Method was found to be not as overly conservative as the ACI-318 (2011) code provisions, and also not to overestimate the ultimate shear strength of high strength PC girders as the AASHTO LRFD (2010) code provisions. Moreover, the proposed UH-Method was found fairly accurate and not exceedingly conservative in predicting the concrete contribution to shear for concrete strength up to 117 MPa (17000 psi).

Keywords： shear design high strength concrete prestressed girders full-scale tests

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Forty Years of the Faster-than-Light Research—Review and Prospects

Huang Zhixun

Strategic Study of CAE 2004, Volume 6, Issue 10, Pages 6-23

Abstract:

Work on faster-than-light (superluminal) research has been going on in USA, Europe and PRC since the early work of O. M. Bilanuik and E. C. Sudarshan in 1962 and that of a good working with G. Feinberg at Columbia University in 1967.

According to the original article of A. Einstein in 1905, velocities greater than that of light have no possibility of existence. However, an interesting phenomenon related to the Einstein's article in 1907 have been found, in which the possibility of sending signals in superluminal communication was not completely negated. In this paper, the author tries to bring about split-up to the different subjects of velocity's study，and then, suggests the definition of General Information Velocity (GIV) to make better discussion of those velocity concepts. After rethinking superluminal research in 1962—2003，the author obtains the conclusion that the “faster than the speed of light in vacuum” is a realizable scientific statement.

Keywords： relalivity quantum mechanics superluminal (faster-than-light) tachyons negative velocity information velocity

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The Trends of Water Quality Change in the Yangtze River and the Yellow River in Last 40 Years

Chen Jingsheng,Xia Xinghui,Hong Song

Strategic Study of CAE 2000, Volume 2, Issue 3, Pages 54-58

Abstract:

The trends of water quality change in the Yangtze River and the Yellow River in last 40 years were

Keywords： the Yangtze River the Yellow River water quality change

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Deeply missing my career idol and role model ― Professor Perry L. McCarty

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 9, doi: 10.1007/s11783-023-1717-x

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Urban watershed management under rapid urbanization

Pengfei DU, Haifeng JIA, Shaw L. YU

Frontiers of Environmental Science & Engineering 2012, Volume 6, Issue 5, Pages 595-595 doi: 10.1007/s11783-012-0452-5

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Recombinant aspartate aminotransferase-catalyzed synthesis of L-4-fluorophenylalanine

CHEN Meijuan, JIA Honghua, CHEN Yongsheng, JIANG Min, WEI Ping

Frontiers of Chemical Science and Engineering 2008, Volume 2, Issue 2, Pages 220-223 doi: 10.1007/s11705-008-0041-0

Abstract: L-4-Fluorophenylalanine (FPhe) was prepared from 4-fluorophenylpyruvate (FPPA) catalyzed by aspartateconditions: 37°C, pH value range of 5.0–8.0, 5.5 mass ratio of cell to FPPA, 0.6% (w/v) of Tween 80, 7.08 g/LFPPA, and 1.6 of molar ratio of L-Asp to FPPA.

Keywords： L-4-Fluorophenylalanine Asp-AT aspartate aminotransferase 4-fluorophenylpyruvate FPPA

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Effects of different doses of cadmium on secondary metabolites and gene expression in Artemisia annua L.

Liangyun Zhou,Guang Yang,Haifeng Sun,Jinfu Tang,Jian Yang,Yizhan Wang,Thomas Avery Garran,Lanping Guo

Frontiers of Medicine 2017, Volume 11, Issue 1, Pages 137-146 doi: 10.1007/s11684-016-0486-3

Abstract: The effects of different Cd concentrations (0, 20, 60, and 120 μmol/L) on the biosynthesis of Artemisia annua L. were examined.The results showed that the application of treatment with 60 and 120 μmol/L Cd for 3 days significantlyThe concentrations of artemisinic acid, arteannuin B, and artemisinin in the 120 μmol/L Cd-treated;DBR2, ALDH1, and DXR were up-regulated in the 120 μmol/L

Keywords： Cd secondary metabolites gene expressions Artemisia annua L.